5-(Carboxymethyl)-2-chlorobenzoic acid → 2-Chloro-5-(2-hydroxyethyl)benzaldehyde

HRID 446366

反応式

HRID 446366 の反応式
[C:1]([CH2:4][C:5]1[CH:6]=[CH:7][C:8]([Cl:14])=[C:9]([CH:13]=1)[C:10](O)=[O:11])(O)=[O:2]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:14][C:8]1[CH:7]=[CH:6][C:5]([CH2:4][CH2:1][OH:2])=[CH:13][C:9]=1[CH:10]=[O:11]

参加物

4

反応物 1

HCID 579893705-(Carboxymethyl)-2-chlorobenzoic acid2 回

生成物 1

HCID 579893312-Chloro-5-(2-hydroxyethyl)benzaldehyde

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

Manganese (IV) dioxide (1.00 g) was added to a solution of 2-(4-chloro-3-(hydroxymethyl)phenyl)ethanol [Aromatic Intermediate 7, step c] (0.200 g) in DCM (5 mL), and the resulting suspension was stirred at room temperature overnight. The mixture was then filtered through Celite, washing the residue well with DCM. The filtrate and washings were concentrated in vacuo to afford the subtitled compound as a colourless oil. Yield 0.197 g.

後処理

  1. filtrationThe mixture was then filtered through Celite
  2. washwashing the residue well with DCM
  3. concentrationThe filtrate and washings were concentrated in vacuo

出典と根拠

ORDレコード
ord-688b5b0f2740451e80c3bf6daee4ac20
出典データセット
uspto-grants-2013_07
特許番号
US08476265B2

関連ノート

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