Hydrochloric Acid → (1S)-2-morpholin-4-yl-1-phenylethanamine dihydrochloride

HRID 44638ノート

反応式

HRID 44638 の反応式
[N:1]1([CH2:7][C@@H:8]([NH:15]C(=O)OC(C)(C)C)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[ClH:23]>ClCCl.O1CCOCC1.C(OCC)C>[ClH:23].[ClH:23].[N:1]1([CH2:7][C@H:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[NH2:15])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 57444157Tert-butyl (1S)-2-morpholin-4-yl-1-phenylethylcarbamate

生成物 1

HCID 57463845(1S)-2-morpholin-4-yl-1-phenylethanamine dihydrochloride収率 90%

試薬・触媒・溶媒 3

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

A solution of 11.58 g (0.0378 mol) of tert-butyl (1S)-2-morpholin-4-yl-1-phenylethylcarbamate in 100 mL of dichloromethane was treated with 120 mL of HCl 4M in dioxane and stirred for 18 hours. The mixture was diluted with diethylether and the product filtered (9.48 g, 90% yield).

後処理

  1. filtrationthe product filtered (9.48 g, 90% yield)

出典と根拠

ORDレコード
ord-844ed63e57b24cd986691df297edc7cf
出典データセット
uspto-grants-2013_09
特許番号
US08541429B2

反応ノート

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