Triethylamine → N-(2,2-Dimethoxyethyl)-N-ethyl-3-(4-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanamide

HRID 446424ノート

反応式

HRID 446424 の反応式
C(P1(=O)OP(CCC)(=O)OP(CCC)(=O)[O:5]1)CC.[CH:19]([C:22]1[S:23][CH:24]=[C:25]([C:27]([N:29]2[CH2:34][C:33]3([CH2:39][CH2:38][N:37]([CH2:40][CH2:41][C:42]4[CH:55]=[CH:54][C:45]([CH2:46][CH2:47][O:48][CH2:49]CC(O)=O)=[CH:44][CH:43]=4)[CH2:36][CH2:35]3)[O:32][CH2:31][CH2:30]2)=[O:28])[N:26]=1)([CH3:21])[CH3:20].[CH2:56]([NH:58][CH2:59][CH:60]([O:63][CH3:64])[O:61][CH3:62])[CH3:57].C(N([CH2:70][CH3:71])CC)C>CN(C=O)C>[CH3:62][O:61][CH:60]([O:63][CH3:64])[CH2:59][N:58]([CH2:70][CH3:71])[C:56](=[O:5])[CH2:57][CH2:49][O:48][CH2:47][CH2:46][C:45]1[CH:54]=[CH:55][C:42]([CH2:41][CH2:40][N:37]2[CH2:38][CH2:39][C:33]3([O:32][CH2:31][CH2:30][N:29]([C:27]([C:25]4[N:26]=[C:22]([CH:19]([CH3:21])[CH3:20])[S:23][CH:24]=4)=[O:28])[CH2:34]3)[CH2:35][CH2:36]2)=[CH:43][CH:44]=1

参加物

6

反応物 4

HCID 8471TriethylamineHCID 111923Propylphosphonic anhydrideHCID 3020444N-ethyl-2,2-dimethoxyethanamineHCID 462387963-(4-(2-(4-(2-Isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoic acid

生成物 1

HCID 58168626N-(2,2-Dimethoxyethyl)-N-ethyl-3-(4-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
20 °C

実験手順

T3P (1.6M in THF, 0.33 mL) was added dropwise to a stirred solution of 3-(4-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoic acid [Example 1, step e] (0.3 g) and N-ethyl-2,2-dimethoxyethanamine [U.S. Pat. No. 2,707,186] (0.062 g) and triethylamine (0.46 mL) in DMF (7 mL). The reaction mixture was stirred at 20° C. for 3 hours. The mixture was partitioned between ethyl acetate and brine, the organic layer was washed with brine (×2), dried, filtered and the solvent evaporated under reduced pressure to yield the subtitled compound. Yield 0.26 g.

後処理

  1. customThe mixture was partitioned between ethyl acetate and brine
  2. washthe organic layer was washed with brine (×2)
  3. customdried
  4. filtrationfiltered
  5. customthe solvent evaporated under reduced pressure

出典と根拠

ORDレコード
ord-635369e516ee4151810a388372fe28aa
出典データセット
uspto-grants-2013_07
特許番号
US08476265B2

反応ノート

読み込み中…