化工社化工社 化学情報印刷レポート · 研究参考用
Diethyl Ether → N'-(1-acetylpiperidin-4-ylidene)benzohydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Benzoylhydrazine | HCID 11955 | — |
| 反応物 | N-Acetyl-4-piperidone | HCID 122563 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N'-(1-acetylpiperidin-4-ylidene)benzohydrazide | HCID 57531701 | 83% |
反応手順
20 g (0.142 mol) of 1-acetyl-4-piperidone were dissolved in 400 mL of absolute ethanol and 21.2 g (0.156 mol) of benzoylhydrazine were added. The resulting solution was refluxed for 6 hours under stirring. The solvent was then removed in vacuo and the residue partitioned between dichloromethane and water. The organic layer was dried over sodium sulfate and evaporated to dryness. The residue was triturated with diethylether and 30 g (83% yield) of the title compound were collected by filtration.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541429B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-d168168c723d46c08635a1699a165a5d |
| 出典メモ | uspto-grants-2013_09 |