Hydrochloric Acid → (1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine hydrochloride

HRID 44652

反応式

HRID 44652 の反応式
C(OC([NH:8][C@@:9]([CH3:24])([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:10]([N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)=[O:11])=O)(C)(C)C.[ClH:25]>O1CCOCC1>[ClH:25].[CH3:24][C@:9]([NH2:8])([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:10]([N:12]1[CH2:13][CH2:14][O:15][CH2:16][CH2:17]1)=[O:11]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 57444165tert-butoxycarbonyl-(1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine

生成物 1

HCID 57444166(1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

A solution of 630 mg (1.884 mmol) of N-(tert-butoxycarbonyl)-(1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine in 20 mL of dioxane was treated with 2.5 mL of HCl 4N in dioxane overnight. The solvent was removed under vacuo and the solid was triturated with diethylether yielding 560 mg of the title compound.

後処理

  1. customThe solvent was removed under vacuo
  2. customthe solid was triturated with diethylether yielding 560 mg of the title compound

出典と根拠

ORDレコード
ord-015e1834be00428fb7598a2baa2a1816
出典データセット
uspto-grants-2013_09
特許番号
US08541429B2

関連ノート

読み込み中…