HCID 86663436、化合物 → HCID 86663435、化合物

HRID 446526ノート

反応式

HRID 446526 の反応式
[CH3:1][N:2]([CH2:10][CH2:11][CH2:12][N:13]([CH3:25])[C:14]([C:16]1[CH:21]=[CH:20][C:19]([N+:22]([O-])=O)=[CH:18][CH:17]=1)=[O:15])[C:3](=[O:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6].[H][H]>CO.[C].[Pd]>[NH2:22][C:19]1[CH:20]=[CH:21][C:16]([C:14]([N:13]([CH3:25])[CH2:12][CH2:11][CH2:10][N:2]([CH3:1])[C:3](=[O:9])[O:4][C:5]([CH3:8])([CH3:6])[CH3:7])=[O:15])=[CH:17][CH:18]=1

参加物

5

反応物 2

HCID 86663436HCID 86663436、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 86663435HCID 86663435、化合物収率 101.2%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

A solution of the compound (162 mg, 0.461 mmol) obtained in Example 28c in methanol (5 mL) was added to 10% palladium-carbon (dry; 16 mg), and the atmosphere in the system was replaced with a hydrogen atmosphere, and then the mixture was stirred at room temperature for 1.5 hours. The atmosphere in the system was replaced with a nitrogen atmosphere, and the mixture was filtered through celite. The solvent was evaporated under reduced pressure to give the title compound (150 mg; yield, 100%) as a colorless oily substance.

後処理

  1. filtrationthe mixture was filtered through celite
  2. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-fad430c227684d8f9cf19738c19f5d7e
出典データセット
uspto-grants-2013_07
特許番号
US08476253B2

反応ノート

読み込み中…