2-(4-Aminophenyl)-N-{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}-N-methylacetamide → 1-{2-[{6-[(4-{2-[{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)amino]-2-oxoethyl}phenyl)amino]hexanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

HRID 446550ノート

反応式

HRID 446550 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([N:11]([CH2:13][CH2:14][CH2:15][N:16]([C:18](=[O:65])[CH2:19][O:20][C@@H:21]2[C:29]3([CH2:34][CH2:33][N:32]([CH2:35][CH2:36][C@:37]4([C:58]5[CH:63]=[CH:62][C:61]([F:64])=[CH:60][CH:59]=5)[O:41][CH2:40][N:39]([C:42](=[O:57])[C:43]5[CH:48]=[C:47]([C:49]([F:52])([F:51])[F:50])[CH:46]=[C:45]([C:53]([F:56])([F:55])[F:54])[CH:44]=5)[CH2:38]4)[CH2:31][CH2:30]3)[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:22]2)[CH3:17])[CH3:12])=[O:10])=[CH:4][CH:3]=1.[C:66]1([C:94]2[CH:99]=[CH:98][CH:97]=[CH:96][CH:95]=2)[CH:71]=[CH:70][CH:69]=[CH:68][C:67]=1[NH:72][C:73](=[O:93])[O:74][CH:75]1[CH2:80][CH2:79][N:78]([CH2:81][CH2:82][N:83]([CH3:92])[C:84](=[O:91])[CH2:85][CH2:86][CH2:87][CH2:88][CH:89]=O)[CH2:77][CH2:76]1>>[C:66]1([C:94]2[CH:95]=[CH:96][CH:97]=[CH:98][CH:99]=2)[CH:71]=[CH:70][CH:69]=[CH:68][C:67]=1[NH:72][C:73](=[O:93])[O:74][CH:75]1[CH2:80][CH2:79][N:78]([CH2:81][CH2:82][N:83]([C:84](=[O:91])[CH2:85][CH2:86][CH2:87][CH2:88][CH2:89][NH:1][C:2]2[CH:7]=[CH:6][C:5]([CH2:8][C:9]([N:11]([CH2:13][CH2:14][CH2:15][N:16]([C:18](=[O:65])[CH2:19][O:20][C@@H:21]3[C:29]4([CH2:30][CH2:31][N:32]([CH2:35][CH2:36][C@:37]5([C:58]6[CH:63]=[CH:62][C:61]([F:64])=[CH:60][CH:59]=6)[O:41][CH2:40][N:39]([C:42](=[O:57])[C:43]6[CH:44]=[C:45]([C:53]([F:54])([F:56])[F:55])[CH:46]=[C:47]([C:49]([F:50])([F:51])[F:52])[CH:48]=6)[CH2:38]5)[CH2:33][CH2:34]4)[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:22]3)[CH3:17])[CH3:12])=[O:10])=[CH:4][CH:3]=2)[CH3:92])[CH2:77][CH2:76]1

参加物

3

反応物 2

HCID 866634522-(4-Aminophenyl)-N-{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}-N-methylacetamideHCID 867619011-{2-[Methyl(6-oxohexanoyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate

生成物 1

HCID 867619091-{2-[{6-[(4-{2-[{3-[({[(2S)-1'-{2-[(5R)-3-[3,5-Bis(trifluoromethyl)benzoyl]-5-(4-fluorophenyl)-1,3-oxazolidin-5-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl]oxy}acetyl)(methyl)amino]propyl}(methyl)amino]-2-oxoethyl}phenyl)amino]hexanoyl}(methyl)amino]ethyl}piperidin-4-yl biphenyl-2-ylcarbamate収率 32%

実験手順

The compound (194 mg, 0.219 mmol) obtained in Example 57b and the compound (102 mg, 0.219 mmol) obtained in Example 4g were used to give the title compound (95 mg; yield, 32%) as a white solid according to the method described in Example 41b.

出典と根拠

ORDレコード
ord-5308faacdfa84e06bf3fe0d8ab10447b
出典データセット
uspto-grants-2013_07
特許番号
US08476253B2

反応ノート

読み込み中…