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1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 86663477、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 反応物 | tert-butyl N-methyl-N-(3-(methylamino)propyl)carbamate | HCID 17868293 | — |
| 反応物 | 2-Bromo-1,3-benzothiazole-6-carboxylic acid | HCID 45789628 | — |
| 生成物 | HCID 86663477 | HCID 86663477 | 77.1% |
反応手順
The compound (100 mg, 0.387 mmol) obtained in Example 93a, tert-butyl methyl[3-(methylamino)propyl]carbamate (78 mg, 0.387 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (89 mg, 0.464 mmol) were used to give the title compound (132 mg; yield, 77%) as a yellow oily substance according to the method described in Example 89b.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08476253B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-6e12ee81a834406eab9991c10baa900a |
| 出典メモ | uspto-grants-2013_07 |