関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diazomethane | HCID 9550 | — |
| 反応物 | 4-tert-Butylcinnamic acid ethyl ester | HCID 13601177 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Ethyl 2-(4-tert-butylphenyl)cyclopropanecarboxylate | HCID 615698 | 84% |
反応手順
To a −40° C. solution of (E)-ethyl 3-(4-tert-butylphenyl)acrylate (1.0 g, 4.3 mol) in ether (20 mL), freshly prepared diazomethane was added dropwise over 10 minutes. Pd(OAc)2 (30 mg, 0.133 mol) was then added. The reaction mixture was stirred for another 10 min at −40° C., and then filtered through a pad of Celite® and precipitate washed with ether. The filtrate was concentrated in vacuo and the crude material was then purified via silica gel column chromatography to afford ethyl 2-(4-tert-butylphenyl)cyclopropanecarboxylate (0.9 g, 84%) as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08481532B2 |
|---|
| 出典データセット | uspto-grants-2013_07 |
|---|
| ORD ID | ord-7ba020a4d3a34f9290a331804c6f7c81 |
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| 出典メモ | uspto-grants-2013_07 |
|---|
