Hydrochloric Acid → (6-Methylpyridin-2-yl)methanol hydrochloride

HRID 446815

反応式

HRID 446815 の反応式
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[N:7]=1)(=O)C.[ClH:13]>>[ClH:13].[CH3:12][C:8]1[N:7]=[C:6]([CH2:5][OH:4])[CH:11]=[CH:10][CH:9]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 291137(6-Methylpyridin-2-yl)methyl acetate

生成物 1

HCID 18413908(6-Methylpyridin-2-yl)methanol hydrochloride

実験手順

A solution of (6-methylpyridin-2-yl)methyl acetate (1.0 g) in concentrated HCl (3 mL) was refluxed for 1 h. The reaction mixture was then concentrated in vacuo to obtain the crude product. The crude material was azeotroped with toluene, and the residue obtained was filtered and dried in vacuo to afford (6-methylpyridin-2-yl)methanol hydrochloride (811 mg) as a solid.

後処理

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. customto obtain the crude product
  3. customThe crude material was azeotroped with toluene
  4. customthe residue obtained
  5. filtrationwas filtered
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-fbf72e3296044ccb8ffa6a04d73dd71d
出典データセット
uspto-grants-2013_07
特許番号
US08481534B2

関連ノート

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