Dimethylmaleic anhydride → 4,5-Dimethylpyridazine-3,6-diol

HRID 447104

反応式

HRID 447104 の反応式
Cl.[NH2:2][NH2:3].[CH3:4][C:5]1=[C:6]([CH3:12])[C:7]([O:9][C:10]1=O)=[O:8]>O>[CH3:4][C:5]1[C:10](=[O:9])[NH:2][NH:3][C:7](=[O:8])[C:6]=1[CH3:12]

参加物

4

反応物 2

HCID 13010Dimethylmaleic anhydrideHCID 115031Hydrazinium chloride

生成物 1

HCID 2422804,5-Dimethylpyridazine-3,6-diol収率 99.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Hydrazine hydrochloride (58 g, 552 mmol) is dissolved in hot water (300 mL) and dimethyl maleic anhydride (58 g, 460 mmol) is added in portions and the suspension stirred at reflux for 16 h. The suspension is cooled down to room temperature and the precipitate is filtered, washed with water and dried at 40° C. under vacuum to yield 4,5-dimethyl-1,2-dihydro-pyridazine-3,6-dione (36) (64 g, 99%).

後処理

  1. temperatureat reflux for 16 h
  2. filtrationthe precipitate is filtered
  3. washwashed with water
  4. customdried at 40° C. under vacuum

出典と根拠

ORDレコード
ord-0327013cf966424c9a9f534b8b90572f
出典データセット
uspto-grants-2013_07
特許番号
US08481542B2

関連ノート

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