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Hydrochloric Acid → 2-(Ethylsulfanyl)-5-methylbenzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-Fluoro-5-methylbenzonitrile | HCID 2774584 | — |
| 反応物 | Sodium ethanethiolate | HCID 4459711 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(Ethylsulfanyl)-5-methylbenzonitrile | HCID 66877145 | 87.1% |
反応手順
(Step 1) A mixture of 2-fluoro-5-methylbenzonitrile (7.5 g) and sodium ethanethiolate (4.9 g) was stirred in N,N-dimethylformamide (30 ml) at room temperature for 3 hr. The reaction solution was treated with 1N hydrochloric acid, and extracted with ethyl acetate. The extract was washed with saturated brine, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure to give 2-(ethylsulfanyl)-5-methylbenzonitrile (8.57 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08481569B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-335dd0ffdb9d42afbf7618b7a5188e88 |
| 出典メモ | uspto-grants-2013_07 |