反応式
[N+:1]([CH3:4])([O-:3])=[O:2].[CH3:5][N:6]1[CH2:11][CH2:10][C:9](=[O:12])[CH2:8][CH2:7]1>C(O)C.C[O-].[Na+]>[CH3:5][N:6]1[CH2:11][CH2:10][C:9]([CH2:4][N+:1]([O-:3])=[O:2])([OH:12])[CH2:8][CH2:7]1参加物
5
実験手順
Nitromethane (6.6 mL, 122.0 mmol) and sodium methoxide (0.94 mL of 25 wt % in methanol, 4.1 mmol) were added to a solution of 1-methyl-4-piperidone (10 mL, 81.3 mmol) in ethanol (10 mL). After 30 minutes more ethanol (15 mL) was added to facilitate stirring. The reaction mixture was stirred at ambient temperature for 2 days and then filtered. The isolated solid was rinsed with ether to provide 10.39 g of 1-methyl-4-nitromethylpiperidin-4-ol as a white powder. An additional 1.18 g was isolated from the filtrate.
後処理
- stirringThe reaction mixture was stirred at ambient temperature for 2 days
- filtrationfiltered
- washThe isolated solid was rinsed with ether
出典と根拠
- ORDレコード
- ord-171affc250c54ee99467abab81fe1169
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541438B2
関連ノート
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