Isopropyl isocyanate → 1-N-i-Propylcarbamoyloxindole
反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH:11]([N:14]=[C:15]=[O:16])([CH3:13])[CH3:12]>C1(C)C=CC=CC=1>[CH:11]([NH:14][C:15]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10])=[O:16])([CH3:13])[CH3:12]参加物
4
実験手順
To a stirred suspension of 5.0 g. (37.6 mmole) of 2-oxindole in 50 ml. of toluene was added 8.0 g. (94.0 mmole) of isopropyl isocyanate, and the mixture was heated under reflux for 6 hours. The reaction mixture was allowed to cool and then it was stirred at room temperature overnight. The solvent was removed by evaporation in vacuo, and the residue was dissolved in hot cyclohexane. The solution was allowed to cool and the solid was collected by filtration, giving 7.0 g. of the title compound, m.p. 84°-85.5° C., as pink crystals.
後処理
- additionTo a stirred suspension of 5.0 g
- temperatureunder reflux for 6 hours
- temperatureto cool
- customThe solvent was removed by evaporation in vacuo
- dissolutionthe residue was dissolved in hot cyclohexane
- temperatureto cool
- filtrationthe solid was collected by filtration
- customgiving 7.0 g
出典と根拠
- ORDレコード
- ord-2dd8beb060374261b699a38de66f5256
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04725616
反応ノート
読み込み中…