Phenyl isocyanate → Methyl 1-N-(phenyl)carbamoyl-5-chlorooxindole-3-carboxylate

HRID 4481ノート

反応式

HRID 4481 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH:5]2[C:12]([O:14][CH3:15])=[O:13].[C:16]1([N:22]=[C:23]=[O:24])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C1(C)C=CC=CC=1>[C:16]1([NH:22][C:23]([N:7]2[C:8]3[C:4](=[CH:3][C:2]([Cl:1])=[CH:10][CH:9]=3)[CH:5]([C:12]([O:14][CH3:15])=[O:13])[C:6]2=[O:11])=[O:24])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

参加物

4

反応物 2

HCID 7672Phenyl isocyanateHCID 21282067methyl 5-chloro-2-oxo-2,3-dihydro-1H-indole-3-carboxylate

生成物 1

HCID 14097011Methyl 1-N-(phenyl)carbamoyl-5-chlorooxindole-3-carboxylate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To 6.0 g. (0.027 mole) of methyl 5-chlorooxindole-3-carboxylate in 200 ml. of toluene was added 5.25 ml. (0.048 mole) of phenylisocyanate and the resulting reaction mixture heated to reflux overnight. The reaction mixture was cooled and diluted with petroleum ether to give, after filtration and drying, 2.0 g. of the desired product.

後処理

  1. temperatureheated
  2. temperatureto reflux overnight
  3. temperatureThe reaction mixture was cooled
  4. customto give
  5. filtrationafter filtration
  6. customdrying

出典と根拠

ORDレコード
ord-bbeceddc0faf432ab9c414f3a0a0c3be
出典データセット
uspto-grants-1988_02
特許番号
US04725616

反応ノート

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