化工社化工社 化学情報印刷レポート · 研究参考用
Ethanol → ethyl (2R)-5-oxopyrrolidine-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | D-Pyroglutamic acid | HCID 439685 | — |
| 溶媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | ethyl (2R)-5-oxopyrrolidine-2-carboxylate | HCID 643508 | — |
反応手順
To a solution of D-pyroglutamic acid (compound I-A, 20.4 g, 0.16 mol) in 100 mL of EtOH, 1.2 mL of conc. sulfuric acid was added. The mixture was heated under reflux overnight. Solvent was removed under reduced pressure to give (R)-ethyl 5-oxopyrrolidine-2-carboxylate (compound II-AA).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541418B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-a7bce6362165468fa455f7ec24641f1b |
| 出典メモ | uspto-grants-2013_09 |