Ethanol → ethyl (2R)-5-oxopyrrolidine-2-carboxylate

HRID 44810

反応式

HRID 44810 の反応式
[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@@H:2]1[C:7]([OH:9])=[O:8].[CH3:10][CH2:11]O>S(=O)(=O)(O)O>[O:6]=[C:5]1[NH:1][C@@H:2]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:3][CH2:4]1

参加物

4

反応物 2

HCID 702EthanolHCID 439685D-Pyroglutamic acid

生成物 1

HCID 643508ethyl (2R)-5-oxopyrrolidine-2-carboxylate

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

To a solution of D-pyroglutamic acid (compound I-A, 20.4 g, 0.16 mol) in 100 mL of EtOH, 1.2 mL of conc. sulfuric acid was added. The mixture was heated under reflux overnight. Solvent was removed under reduced pressure to give (R)-ethyl 5-oxopyrrolidine-2-carboxylate (compound II-AA).

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux overnight
  3. customSolvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-a7bce6362165468fa455f7ec24641f1b
出典データセット
uspto-grants-2013_09
特許番号
US08541418B2

関連ノート

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