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2-(Tributylstannyl)-1,3-thiazole → (R)-8-cyclopentyl-7-ethyl-5-methyl-2-(2-(thiazol-2-yl)-1H-imidazol-1-yl)-7,8-dihydropteridin-6(5H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Tributylstannyl)-1,3-thiazole | HCID 2763259 | — |
| 反応物 | (R)-2-(2-bromo-1H-imidazol-1-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one | HCID 58405307 | — |
| 生成物 | (R)-8-cyclopentyl-7-ethyl-5-methyl-2-(2-(thiazol-2-yl)-1H-imidazol-1-yl)-7,8-dihydropteridin-6(5H)-one | HCID 58405426 | — |
反応手順
The title compound was prepared similarly to the methods described in Example 54, with (R)-2-(2-bromo-1H-imidazol-1-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 65) used instead of (R)-2-(4-bromo-1H-imidazol-1-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 43) and with 2-(tributylstannyl)thiazole instead of 4-(tributylstannyl)thiazole. LCMS: 410.1 m/z (M+H)+; ret. Time: 3.11 min (Analytical Method A).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541418B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-666a5a2a967d4c9f98a6f91d88a29949 |
| 出典メモ | uspto-grants-2013_09 |