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Potassium Carbonate → 2-(1-Methoxycarbonylethoxy)benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl 2-bromopropionate | HCID 95576 | — |
| 反応物 | 2-Hydroxybenzene-1-sulfonamide | HCID 637546 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2-(1-Methoxycarbonylethoxy)benzenesulfonamide | HCID 22152837 | 80.7% |
反応手順
34.6 g of 2-hydroxybenzenesulfonamide and 55.3 g of potassium carbonate are added to 800 ml of acetonitrile. With efficient stirring, 33.4 g of methyl 2-bromopropionate are added dropwise over 10 minutes and the suspension is then heated for 5 hours to 45° C. After the reaction mixture has cooled, the precipitated salts are isolated and the filtrate is concentrated in vacuo. The residue is recrystallised from ethanol, affording 41.8 g of 2-(1-methoxycarbonylethoxy)- benzenesulfonamide with a melting point of 140°-142° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04726836 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-580394b4ef7a438bb6f3a79f841eee23 |
| 出典メモ | uspto-grants-1988_02 |