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Isopropyl chloroformate → Isopropyl 4-({6-[5-(methylsulfonyl)indolin-1-yl]pyrimidin-4-yl}oxy)piperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isopropyl chloroformate | HCID 7917 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 5-(Methylsulfonyl)-1-(6-(piperidin-4-yloxy)pyrimidin-4-yl)indoline | HCID 66709668 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Isopropyl 4-({6-[5-(methylsulfonyl)indolin-1-yl]pyrimidin-4-yl}oxy)piperidine-1-carboxylate | HCID 25260830 | — |
反応手順
To a solution of 4b (0.12 mmol) and triethylamine (0.2 mL, 12 eq) in 1 mL of DCM, was added the isopropyl chloroformate (1.3 eq). The mixture was stirred at room temperature for 22 h and the solvent volume was reduced to 0.7 mL under a stream of nitrogen. The residue was purified by preparative HPLC to afford 4-1, LCMS 461.2 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08481731B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-f523c95db29e4f6bb646ad5b2e32ebe4 |
| 出典メモ | uspto-grants-2013_07 |