Leucine, N-carboxy-, N-benzyl ester, L- → N-[N-[(Phenylmethoxy)carbonyl]-L-leucyl]-L-norleucinol

HRID 448754

反応式

HRID 448754 の反応式
[C:1]1([CH2:7][O:8][C:9]([NH:11][C@H:12]([C:17]([OH:19])=O)[CH2:13][CH:14]([CH3:16])[CH3:15])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:20][C@H:21]([CH2:26][OH:27])[CH2:22][CH2:23][CH2:24][CH3:25]>>[C:1]1([CH2:7][O:8][C:9]([NH:11][C@H:12]([C:17]([NH:20][C@H:21]([CH2:26][OH:27])[CH2:22][CH2:23][CH2:24][CH3:25])=[O:19])[CH2:13][CH:14]([CH3:15])[CH3:16])=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

3

反応物 2

HCID 74840Leucine, N-carboxy-, N-benzyl ester, L-HCID 5494388(2S)-2-Amino-1-hexanol

生成物 1

HCID 15168139N-[N-[(Phenylmethoxy)carbonyl]-L-leucyl]-L-norleucinol収率 58%

実験手順

N-[(phenylmethoxy)carbonyl]-L-leucine was used instead of 1-[[(phenylmethoxy)carbonyl]amino]cyclohexanecarboxylic acid, and L-norleucinol was used instead of L-valinol in the process according to Reference Example 178 to obtain 421 mg (58%) of the title compound.

出典と根拠

ORDレコード
ord-d7d5a8b2750f42bfbf6ced8702089204
出典データセット
uspto-grants-2013_07
特許番号
US08481725B2

関連ノート

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