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Methyl 1-aminocyclohexanoate → 1-[[[4-[2-[4-(4-Morpholinyl)-1-piperazinyl]-4-thiazolyl]phenyl]carbonyl]amino]cyclohexanecarboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 1-aminocyclohexanoate | HCID 4048819 | — |
| 反応物 | 4-[2-[4-(4-Morpholinyl)-1-piperazinyl]-4-thiazolyl]benzoic acid hydrobromide | HCID 67181771 | — |
| 生成物 | 1-[[[4-[2-[4-(4-Morpholinyl)-1-piperazinyl]-4-thiazolyl]phenyl]carbonyl]amino]cyclohexanecarboxylic acid methyl ester | HCID 67182490 | — |
反応手順
4.50 g (9.90 mmol) of 4-[2-[4-(4-morpholinyl)-1-piperazinyl]-4-thiazolyl]benzoic acid hydrobromide was used instead of 4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzoic acid hydrobromide, and 1.57 g (9.90 mmol) of 1-aminocyclohexanecarboxylic acid methyl ester was used instead of 1-aminocyclohexanecarboxylic acid phenylmethyl ester in the process according to Reference Example 210 to obtain 5.08 g (quantitative) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08481725B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-fe988b498058463d9769fa9d6dd5c79a |
| 出典メモ | uspto-grants-2013_07 |