Dimethylamine → Methyl 6-dimethylamino-4-(trifluoromethyl)-pyridine-3-carboxylate

HRID 448830

反応式

HRID 448830 の反応式
Cl[C:2]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[CH3:16][NH:17][CH3:18]>O>[CH3:16][N:17]([CH3:18])[C:2]1[N:3]=[CH:4][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1

参加物

4

反応物 2

HCID 674DimethylamineHCID 2775340Methyl 6-chloro-4-(trifluoromethyl)nicotinate

生成物 1

HCID 68933112Methyl 6-dimethylamino-4-(trifluoromethyl)-pyridine-3-carboxylate

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

A mixture of 2.5 g (10.43 mmol) of methyl 6-chloro-4-(trifluoromethyl)nicotinate and 18.4 ml (146 mmol) of a 40% solution of dimethylamine in water is heated at 100° C. for 1 hour. A precipitate is subsequently collected by filtering the cooled mixture and is washed with 150 ml of water. After drying under reduced pressure, 2.3 g of the expected compound are isolated.

後処理

  1. customA precipitate is subsequently collected
  2. filtrationby filtering the cooled mixture
  3. washis washed with 150 ml of water
  4. dry with materialAfter drying under reduced pressure, 2.3 g of the expected compound
  5. customare isolated

出典と根拠

ORDレコード
ord-7244f027bf874f07a57bd81964dfbfcc
出典データセット
uspto-grants-2013_07
特許番号
US08481745B2

関連ノート

読み込み中…