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Water → 2,4-dichloro-N-(1-methyltetrazol-5-yl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 2,4-Dichlorobenzoyl chloride | HCID 66645 | — |
| 反応物 | 1-methyl-1H-tetrazol-5-amine | HCID 138492 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2,4-dichloro-N-(1-methyltetrazol-5-yl)benzamide | HCID 66606525 | — |
反応手順
In a microwave oven, 209 mg (1.0 mmol) of 2,4-dichlorobenzoyl chloride, 198 mg (2.0 mmol) of 1-methyl-5-aminotetrazole and 237 mg (3 mmol) of pyridine in 3 ml of acetonitrile are stirred at 130° C. for 45 min. Water is then added, and the product is filtered off with suction and washed with ether. Yield 80 mg (30%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08481749B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-1e077ed3306f4005a44ab0d8c8cd395b |
| 出典メモ | uspto-grants-2013_07 |