Hydrochloric Acid → HCID 66915521、化合物
反応式
C(OC([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[N:15]=[C:16]([CH:24]3[CH2:27][CH2:26][CH2:25]3)[N:17]3[CH:22]=[CH:21][N:20]=[C:19]([NH2:23])[C:18]=23)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[CH:24]1([C:16]2[N:17]3[CH:22]=[CH:21][N:20]=[C:19]([NH2:23])[C:18]3=[C:14]([C:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=3)[N:15]=2)[CH2:27][CH2:26][CH2:25]1参加物
4
実験手順
To a stirred solution of 4-(8-amino-3-cyclobutyl-imidazo[1,5-a]pyrazin-1-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (300 mg, 1.12 mmol) in 1,4-dioxane (5 mL) was added HCl (4M solution in dioxane, 10 ml) at 10° C. The resulting mixture was stirred at rt. for 3 hr. The solvent was removed under reduced pressure and the resulting residue was used for next step without any further purification. MS (ES+): m/z: 270.13 [MH+], HPLC: tR=1.62 min (OpenLynx, polar—5 min).