4-Bromophenol → HCID 66915512、化合物

HRID 449107ノート

反応式

HRID 449107 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[F:9][C:10]1[C:15](B(O)O)=[C:14]([O:19][CH3:20])[CH:13]=[CH:12][CH:11]=1>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:15]2[C:14]([O:19][CH3:20])=[CH:13][CH:12]=[CH:11][C:10]=2[F:9])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 78084-BromophenolHCID 3294524(2-Fluoro-6-methoxyphenyl)boronic acid

生成物 1

HCID 66915512HCID 66915512、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Into a 100 mL round bottom flask was added 4-bromophenol (2.04 g, 11.8 mmol), 6-fluoro-2-methoxyphenylboronic acid (1.00 g, 5.88 mmol), cupric acetate (1.4 g, 7.70 mmol) and DCM (50 mL). TEA (4.0 mL, 29.0 mmol) was then added followed by 4 A° molecular sieves and the reaction mixture was stirred at rt for 48 h. Reaction mixture was then filtered through celite. The filtrate was concentrated in vacuo to give a residue which was purified by silica gel chromatography, eluting with 5% EtOAc in hexane.

後処理

  1. customReaction mixture
  2. filtrationwas then filtered through celite
  3. concentrationThe filtrate was concentrated in vacuo
  4. customto give a residue which
  5. customwas purified by silica gel chromatography
  6. washeluting with 5% EtOAc in hexane

出典と根拠

ORDレコード
ord-cd7ba9ce95f64e3289938e868bfed921
出典データセット
uspto-grants-2013_07
特許番号
US08481733B2

反応ノート

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