Phenylboronic Acid → 1-Bromo-4-phenoxy-2-(trifluoromethyl)benzene

HRID 449133ノート

反応式

HRID 449133 の反応式
[C:1]1(B(O)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][C:12]=1[C:18]([F:21])([F:20])[F:19]>C(Cl)Cl>[Br:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:13][C:12]=1[C:18]([F:19])([F:20])[F:21]

参加物

4

反応物 2

HCID 66827Phenylboronic AcidHCID 222773074-Bromo-3-(trifluoromethyl)phenol

生成物 1

HCID 669156501-Bromo-4-phenoxy-2-(trifluoromethyl)benzene

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred mixture of phenylboronic acid (1.20 g, 9.85 mmol) and 4-bromo-3-trifluoromethyl-phenol (1.18 g, 4.92 mmol) in DCM (50.00 mL) was added cupric acetate (1.34 g, 7.39 mmol), powdered 4 A molecular sieves and TEA (3.43 mL, 24.6 mmol) at rt. The resulting mixture was then stirred at rt for 24 h at ambient atmosphere. The solvent was then removed under reduced pressure and the resulting residue was purified by flash chromatography (5% EtOAc in hexane).

後処理

  1. customat rt
  2. customThe solvent was then removed under reduced pressure
  3. customthe resulting residue was purified by flash chromatography (5% EtOAc in hexane)

出典と根拠

ORDレコード
ord-d0f483d181af41c48e6df16766390bb5
出典データセット
uspto-grants-2013_07
特許番号
US08481733B2

反応ノート

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