Hydrochloric Acid → Hydrochloric Acid

HRID 449311ノート

反応式

HRID 449311 の反応式
[ClH:1].[NH2:2][C:3]1[N:8]=[C:7]([C:9]2[CH:18]=[C:17]3[C:12]([CH2:13][CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16]3)=[CH:11][CH:10]=2)[CH:6]=[C:5]([N:26]2[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]2)[N:4]=1>O1CCOCC1.CO>[CH3:32][N:29]1[CH2:28][CH2:27][N:26]([C:5]2[CH:6]=[C:7]([C:9]3[CH:18]=[C:17]4[C:12]([CH2:13][CH2:14][NH:15][CH2:16]4)=[CH:11][CH:10]=3)[N:8]=[C:3]([NH2:2])[N:4]=2)[CH2:31][CH2:30]1.[ClH:1]

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 59496680tert-butyl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate

生成物 2

HCID 313Hydrochloric AcidHCID 497794384-(4-Methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

6 mL of 4N HCl in dioxane was added to a solution of tert-butyl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate (0.90 g, 2.1 mmol) in methanol (5 mL). The mixture was stirred at r.t. for 2 h. The mixture was concentrated under reduced pressure. The residue was washed with ether and dried under vacuum to afford the desired product as an HCl salt (0.83 g). Analytic LCMS (M+H)+: m/z=325.4.

後処理

  1. concentrationThe mixture was concentrated under reduced pressure
  2. washThe residue was washed with ether
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-76982313218742ccb3a1a3f9dd696804
出典データセット
uspto-grants-2013_07
特許番号
US08481732B2

反応ノート

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