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Phosgene → 7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-3,4-dihydroisoquinoline-2(1H)-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosgene | HCID 6371 | — |
| 反応物 | 2-Amino-4-(4-chlorophenyl)thiazole | HCID 73241 | — |
| 反応物 | 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt | HCID 67541489 | — |
| 生成物 | 7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-3,4-dihydroisoquinoline-2(1H)-carboxamide | HCID 59496637 | — |
反応手順
This compound was prepared by using procedures analogous to those described for the synthesis of Example 40 starting from 4-(4-chlorophenyl)-1,3-thiazol-2-amine (Aldrich, Cat. #339369), phosgene and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=561.2/563.2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08481732B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-8f7ce4523aad4c3d91400d88e76367e1 |
| 出典メモ | uspto-grants-2013_07 |