Hydrochloric Acid → Hydrochloric Acid

HRID 449391ノート

反応式

HRID 449391 の反応式
[ClH:1].[NH2:2][C:3]1[N:8]=[C:7]([C:9]2[CH:18]=[C:17]3[C:12]([CH2:13][CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16]3)=[CH:11][C:10]=2[F:26])[CH:6]=[C:5]([N:27]2[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]2)[N:4]=1>O1CCOCC1.CO>[F:26][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][C:9]=1[C:7]1[CH:6]=[C:5]([N:27]3[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]3)[N:4]=[C:3]([NH2:2])[N:8]=1)[CH2:16][NH:15][CH2:14][CH2:13]2.[ClH:1]

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 59496598tert-butyl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-6-fluoro-3,4-dihydroisoquinoline-2(1H)-carboxylate

生成物 2

HCID 313Hydrochloric AcidHCID 594966484-(6-Fluoro-1,2,3,4-tetrahydroisoquinolin-7-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

2.0 mL of 4 N HCl in 1,4-dioxane was added to a solution of tert-butyl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-6-fluoro-3,4-dihydroisoquinoline-2(1H)-carboxylate (0.050 g, 0.11 mmol) in methanol (1 mL). The reaction mixture was stirred at r.t. for 30 min The volatiles were removed under reduced pressure to afford the desired product as an HCl salt. Analytic LCMS (M+H)+: m/z=343.1.

後処理

  1. customwere removed under reduced pressure

出典と根拠

ORDレコード
ord-99081ed0d07046a4adcf8006cc3e25a9
出典データセット
uspto-grants-2013_07
特許番号
US08481732B2

反応ノート

読み込み中…