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HRID 449418作成日：2026年10月27日

4-Phenoxyphenyl isocyanate → 7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-(4-phenoxyphenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

https://huagongshe.com/reaction/449418

反応式

関与物質

役割名称HCID仕込み量
反応物4-Phenoxyphenyl isocyanateHCID 2734896—
反応物4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl saltHCID 67541489—
生成物7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-(4-phenoxyphenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamideHCID 49779705—

反応手順

This compound was prepared by using procedures analogous to those described for the synthesis of Example 5 starting from 4-phenoxyphenyl isocyanate (Aldrich, Cat. #478970) and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=536.2.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08481732B2
出典データセットuspto-grants-2013_07
ORD IDord-2077a0a743584dceadb3f3f808a5de4c
出典メモuspto-grants-2013_07