Isoquinolin-5-ol → 1,2,3,4-Tetrahydroisoquinolin-5-ol

HRID 449528

反応式

HRID 449528 の反応式
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([OH:11])[C:5]=2[CH:4]=[CH:3][N:2]=1>C(O)(=O)C>[CH2:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([OH:11])[C:5]=2[CH2:4][CH2:3][NH:2]1

参加物

3

反応物 1

HCID 30386Isoquinolin-5-ol

生成物 1

HCID 139482511,2,3,4-Tetrahydroisoquinolin-5-ol収率 90.2%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Isoquinolin-5-ol (Aldrich, Cat. #H33207)(0.75 g, 5.2 mmol) was dissolved in acetic acid (20.0 mL) in a Parr shaker bottle. The reaction was degassed with nitrogen, and the platinum dioxide (0.050 g) was added. The reaction was charged to 55 Psi hydrogen and shaken. After shaking for 24 h. the reaction was complete. This was filtered to remove the catalyst and concentrated under reduced pressure give a dark amber 1,2,3,4-tetrahydroisoquinolin-5-ol (0.70 g, 90%) as an oil. Analytical LCMS (M+H)+: m/z=150.1.

後処理

  1. customThe reaction was degassed with nitrogen
  2. additionthe platinum dioxide (0.050 g) was added
  3. additionThe reaction was charged to 55 Psi hydrogen
  4. stirringAfter shaking for 24 h. the reaction
  5. filtrationThis was filtered
  6. customto remove the catalyst
  7. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-57265a60d78f4d2fae3da2db3afff653
出典データセット
uspto-grants-2013_07
特許番号
US08481732B2

関連ノート

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