関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 6-Amino-3-chloropyridazine | HCID 21643 | — |
| 反応物 | (1S,4S)-2-Methyl-2,5-diazabicyclo[2.2.1]heptane | HCID 11029795 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 66743079 | HCID 66743079 | — |
反応手順
6-Chloropyridazin-3-amine (200 mg, 1.54 mmol, Eq: 1.00) and (1S,4S)-2-methyl-2,5-diazabicyclo[2.2.1]heptane (693 mg, 6.18 mmol, Eq: 4.00) were combined in a small round bottom flask and heated at 200° C. for 2 hours. The dark glassy residue was dissolved in DCM and purified by chromatography using a gradient of 0% to 25% methanol (with 2.5% ammonium hydroxide) in DCM to give about 100 mg (31.6%) of a brown, viscous oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08481540B2 |
|---|
| 出典データセット | uspto-grants-2013_07 |
|---|
| ORD ID | ord-7cc553233b3c459a91ba6aac9dbc064c |
|---|
| 出典メモ | uspto-grants-2013_07 |
|---|
