Tetrahydrofuran → (S)-6-Amino-2-carbazol-9-yl-hexanoic methyl ester

関与物質

反応手順

10% Pd/C (0.100 g) was added in one portion to a stiffed solution of (S)-Methyl 6-benzyloxycarbonylamino-2-carbazol-9-yl-hexanoate 3 (1.06 g, 2.47 mmol) in a (1:1) mixture of THF (10 mL) and isopropanol (10 mL) under nitrogen atmosphere. The reaction mixture was subsequently stirred under hydrogen atmosphere for 4 h at room temperature. The reaction mixture was filtrated through a celite pad and the filtrate was evaporated under reduced pressure to get (S)-6-amino-2-carbazol-9-yl-hexanoic methyl ester 4 (0.640 g, 85%) as off-white solid.

情報源と証拠