Methyl 4-((tert-butoxycarbonyl)amino)-2,6-dichlorobenzoate → Methyl 4-amino-2,6-dichlorobenzoate

反応式

C(OC([NH:8][C:9]1[CH:18]=[C:17]([Cl:19])[C:12]([C:13]([O:15][CH3:16])=[O:14])=[C:11]([Cl:20])[CH:10]=1)=O)(C)(C)C>OS(O)(=O)=O.CCOC(C)=O>[NH2:8][C:9]1[CH:10]=[C:11]([Cl:20])[C:12]([C:13]([O:15][CH3:16])=[O:14])=[C:17]([Cl:19])[CH:18]=1

参加物

実験手順

A solution of methyl 4-(tert-butoxy carbonylamino)-2,6-dichlorobenzoate (65 g, 0.49 mol) in H2SO4/EtOAc (3 N, 20 mL) was stirred at room temperature for 2 hours. The reaction mixture was filtered, and the solid was collected to afford methyl 4-amino-2,6-dichlorobenzoate (60 g, yield: 92%). 1H NMR (DMSO-d6, 400 MHz) δ 8.40 (brs, 3H), 6.61 (s, 2H), 3.80 (s, 3H).

後処理

filtrationThe reaction mixture was filtered
customthe solid was collected

出典と根拠

ORDレコード: ord-bb69f6630e0b45ebb44fc9a1d6c46dec
出典データセット: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08486950B2

反応ノート

読み込み中…

参加物

反応物 1

HCID 20610066Methyl 4-((tert-butoxycarbonyl)amino)-2,6-dichlorobenzoate

生成物 1

HCID 51341879Methyl 4-amino-2,6-dichlorobenzoate収率 92%

試薬・触媒・溶媒 1

HCID 86628183Ethyl acetate sulfuric acid溶媒

実験手順

後処理

filtrationThe reaction mixture was filtered
customthe solid was collected

出典と根拠

ORDレコード: ord-bb69f6630e0b45ebb44fc9a1d6c46dec
出典データセット: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08486950B2

反応ノート

読み込み中…