Diethyl Ether → 2-Bromo-1-(3-methylphenyl)ethan-1-one

HRID 450025

反応式

HRID 450025 の反応式
[C:1]1([CH3:10])[CH:6]=[CH:5][CH:4]=[C:3]([C:7](=[O:9])[CH3:8])[CH:2]=1.[Br:11]Br.CCOCC>O1CCOCC1>[Br:11][CH2:8][C:7]([C:3]1[CH:2]=[C:1]([CH3:10])[CH:6]=[CH:5][CH:4]=1)=[O:9]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 114553-MethylacetophenoneHCID 24408Bromine

生成物 1

HCID 100361292-Bromo-1-(3-methylphenyl)ethan-1-one

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

To a solution of 1-m-tolyl-ethanone (6.0 g, 44.72 mmol) in dioxane (5 ml), bromine (7.14 g, 44.72 mmol) in dioxane (10 ml) and ether (15 ml) was added and stirred at room temperature for 5 hr. The reaction mixture was poured into ice water and the compound was extracted using ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous sodium sulfate, filtered and then evaporated to give crude 2-bromo-1-m-tolyl-ethanone, 7.6 g (80%). The crude compound obtained was used in the next step without further purification.

後処理

  1. extractionthe compound was extracted
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. customevaporated
  6. customto give crude 2-bromo-1-m-tolyl-ethanone, 7.6 g (80%)

出典と根拠

ORDレコード
ord-0586c48dda1c4b35beae4608fb38fbc0
出典データセット
uspto-grants-2013_07
特許番号
US08486962B2

関連ノート

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