2-Chloro-5-nitrobenzoic acid → 2-Methoxy-5-nitrobenzoic acid

HRID 450080

反応式

HRID 450080 の反応式
Cl[C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:14][O-:15].[Na+]>>[CH3:14][O:15][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

参加物

3

反応物 2

HCID 172872-Chloro-5-nitrobenzoic acidHCID 10942334Sodium Methoxide

生成物 1

HCID 2841632-Methoxy-5-nitrobenzoic acid収率 87%

実験手順

2-Chloro-5-nitro-benzoic acid (3 g, 14 mmol) was added to a solution of freshly prepared sodium methoxide (from sodium (1.36 g, 56 mmol) in dry methanol (15 ml)) and the reaction was heated to reflux for 12 hr. Methanol was evaporated and the reaction mass diluted with water (25 ml). Conc hydrochloric acid was added until the pH was ˜2. The reaction mixture was stirred at room temperature for 30 min, then the precipitate was filtered and washed with water. Drying at 60-70° C. yielded 2-methoxy-5-nitro benzoic acid (2.4 g, 81%).

後処理

  1. temperaturethe reaction was heated
  2. temperatureto reflux for 12 hr
  3. customMethanol was evaporated
  4. additionthe reaction mass diluted with water (25 ml)
  5. additionConc hydrochloric acid was added until the pH was ˜2
  6. filtrationthe precipitate was filtered
  7. washwashed with water
  8. customDrying at 60-70° C.

出典と根拠

ORDレコード
ord-c28a0ce40e1f4638a81ec7db09207937
出典データセット
uspto-grants-2013_07
特許番号
US08486962B2

関連ノート

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