Hydrochloric Acid → 4-(1,3-Oxazol-5-yl)aniline

HRID 450097

反応式

HRID 450097 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:14][CH:13]=[N:12][CH:11]=2)=[CH:6][CH:5]=1)([O-])=O.[Sn].Cl>C(O)C>[O:14]1[C:10]([C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=2)=[CH:11][N:12]=[CH:13]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 27370685-(4-Nitrophenyl)-1,3-oxazoleHCID 5352426Tin atom

生成物 1

HCID 5177474-(1,3-Oxazol-5-yl)aniline収率 91.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 5-(4-nitro-phenyl)-oxazole (500 mg, 2.6 mmol) in ethanol (10 ml) was added tin (620 mg, 5.2 mmol), followed by dropwise addition of concentrated hydrochloric acid (1 ml) and then the reaction was stirred at room temperature for 2 hr. The reaction mixture was filtered and the filtrate evaporated to dryness. The resultant residue was diluted with water (10 ml), basified with saturated bicarbonate solution, then extracted with ethyl acetate. The organic layer was separated, washed with water, dried and concentrated to dryness to yield 4-oxazol-5-yl-phenylamine (380 mg, 90%) as solid.

後処理

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate evaporated to dryness
  3. additionThe resultant residue was diluted with water (10 ml)
  4. extractionextracted with ethyl acetate
  5. customThe organic layer was separated
  6. washwashed with water
  7. customdried
  8. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-41409a87bf4d48bba398abb33b6b2a0f
出典データセット
uspto-grants-2013_07
特許番号
US08486962B2

関連ノート

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