Benzophenone oxime → diphenyl-methanone O-(2-dimethylaminoethyl)-oxime

HRID 450107

反応式

HRID 450107 の反応式
[C:1]1([C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][OH:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.Cl[CH2:18][CH2:19][N:20]([CH3:22])[CH3:21].[OH-].[K+]>CS(C)=O.O>[CH3:21][N:20]([CH3:22])[CH2:19][CH2:18][O:9][N:8]=[C:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 3

HCID 11324Benzophenone oximeHCID 14797Potassium HydroxideHCID 11636816N,N-Dimethylaminoethyl chloride hydrochloride

生成物 1

HCID 10659548diphenyl-methanone O-(2-dimethylaminoethyl)-oxime収率 26.1%

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

実験手順

To a solution of diphenyl-methanone oxime (2 g, 10 mmol) and (2-chloro-ethyl)-dimethyl-amine hydrochloride (1.5 g, 10.4 mmol) in DMSO (20 ml) was added powdered potassium hydroxide (800 mg, 14.3 mmol) and the reaction mixture stirred overnight. The reaction mixture was diluted with water and then extracted with ethyl acetate. The organic layer was washed thoroughly with water and brine, then dried over anhydrous sodium sulphate and filtered. Concentration of the organic layer under reduced pressure gave diphenyl-methanone O-(2-dimethylaminoethyl)-oxime (700 mg, 26%) as a solid.

後処理

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed thoroughly with water and brine
  3. dry with materialdried over anhydrous sodium sulphate
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-421b1d16853c4246955cf68f76229eb0
出典データセット
uspto-grants-2013_07
特許番号
US08486962B2

関連ノート

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