Hydrochloric Acid → HCID 67172481、化合物
反応式
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([C:10]23[CH2:15][CH:14]2[CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11]3)=[CH:2]1.[ClH:23]>O1CCOCC1>[ClH:23].[C:10]12([C:3]3[C:4]4[C:5](=[N:6][CH:7]=[CH:8][CH:9]=4)[NH:1][CH:2]=3)[CH2:15][CH:14]1[CH2:13][NH:12][CH2:11]2参加物
4
実験手順
To tert-butyl 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3-azabicyclo[3.1.0]hexane-3-carboxylate (100 mg, 0.3 mmol) in dioxan (3 ml) was added 1 mL of a 4M solution of HCl in dioxan. The reaction mixture was stirred at RT for 12 h and concentrated to dryness to afford the title compound as a buff colored solid (60 mg), which was used immediately in the following step.
後処理
- concentrationconcentrated to dryness
出典と根拠
- ORDレコード
- ord-c4bafe7ad8674c308292aa6751d2fa3a
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08486964B2
反応ノート
読み込み中…