1H-Pyrazol-3-amine, 5-methyl- → 2-chloro-N-(5-methyl-1H-pyrazol-3-yl)-5-nitropyrimidin-4-amine

反応式

[Cl:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:13]=[C:12](OC(C)C)[NH:11][N:10]=2)[C:5]([N+:18]([O-:20])=[O:19])=[CH:4][N:3]=1.Cl[CH:22]1N([N+]([O-])=O)C=CC(Cl)=N1.CC1NN=C(N)C=1>>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:13]=[C:12]([CH3:22])[NH:11][N:10]=2)[C:5]([N+:18]([O-:20])=[O:19])=[CH:4][N:3]=1

参加物

反応物 3

HCID 931461H-Pyrazol-3-amine, 5-methyl-

HCID 184699722,6-Dichloro-3-nitropyrimidine

HCID 178458615HCID 178458615、化合物

生成物 1

HCID 715389382-chloro-N-(5-methyl-1H-pyrazol-3-yl)-5-nitropyrimidin-4-amine

実験手順

The title compound was prepared using a procedure similar to the one described for the synthesis of Intermediate 30 using 2,6-dichloro-3-nitropyrimidine and 5-methyl-1H-pyrazol-3-amine as the starting materials. LCMS: 255 [M+1].

出典と根拠

ORDレコード: ord-a8393a7fb5724537bad711b9243a0667
出典データセット: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08486966B2

反応ノート

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