化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 2-Nitro-5-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 3-Hydroxy-4-nitrobenzoic acid | HCID 69265 | — |
| 反応物 | N-Hydroxynicotinimidamide | HCID 308113 | — |
| 生成物 | 2-Nitro-5-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)phenol | HCID 67026095 | — |
反応手順
The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 3-hydroxy-4-nitrobenzoic acid (Maybridge). 1H NMR (300 MHz, DMSO-d6) δ 6.51 (d, J=9.1 Hz, 1 H), 6.92-7.31 (s (broad), 1 H), 7.61 (ddd, J=7.9, 4.8, 0.8 Hz, 1 H), 7.68 (dd, J=9.1, 2.4 Hz, 1 H), 8.40 (dt, J=7.9, 2.0 Hz, 1 H), 8.53 (d, J=2.4 Hz, 1 H), 8.77 (dd, J=4.8, 1.6 Hz, 1 H), 9.20 (d, J=1.6 Hz, 1 H) ppm; MS (DCI/NH3) m/z 285 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08486979B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-15f080e4aecf48668e900be016bec499 |
| 出典メモ | uspto-grants-2013_07 |