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2-Chloro-5-nitro-3-(trifluoromethyl)pyridine → 5-(Trifluoromethyl)pyridin-3-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine | HCID 3849140 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-(Trifluoromethyl)pyridin-3-amine | HCID 14051936 | — |
反応手順
A mixture of 2-chloro-5-nitro-3-trifluoromethyl-pyridine (30 mg, 0.13 mmol), 10% Pd/C (3 mg, 10% w/w), and MeOH (5 mL) is stirred under 1 atm of hydrogen for 3 h. The mixture is then filtered over Celite® and concentrated in vacuo to give the title compound as an oil. MS (ESI) m/z 162.9 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541432B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-3b6178c4a1d045a29eced0ae97e978c8 |
| 出典メモ | uspto-grants-2013_09 |