化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 2-Fluoro-5-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | N-Hydroxynicotinimidamide | HCID 308113 | — |
| 反応物 | 3-Cyano-4-fluorobenzoic acid | HCID 2773932 | — |
| 生成物 | 2-Fluoro-5-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile | HCID 67026066 | — |
反応手順
The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 3-cyano-4-fluorobenzoic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ ppm 7.62-7.71 (m, 2 H), 8.54-8.63 (m, 2 H), 8.69 (dd, J=5.9, 2.2 Hz, 1 H), 8.75 (dd, J=4.9, 1.5 Hz, 1 H), 9.30 (dd, J=2.0, 1.0 Hz, 1 H); MS (DCI/NH3) m/z 267 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08486979B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-04b88718c0c942dd8543f9ec4b85e120 |
| 出典メモ | uspto-grants-2013_07 |