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Ammonia → Tert-butyl 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | N-Hydroxynicotinimidamide | HCID 308113 | — |
| 反応物 | 3-(((tert-Butoxycarbonyl)amino)methyl)benzoic acid | HCID 2755929 | — |
| 生成物 | Tert-butyl 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzylcarbamate | HCID 67026201 | — |
反応手順
The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 3-((tert-butoxycarbonylamino)methyl)benzoic acid (Fluka). 1H NMR (300 MHz, DMSO-d6) δ 1.42 (s, 9 H), 4.27 (d, J=6.1 Hz, 2 H), 7.51-7.72 (m, 4 H), 8.01-8.17 (m, 2 H), 8.45 (dt, J=8.1, 1.9 Hz, 1 H), 8.82 (dd, J=5.1, 1.7 Hz, 1H), 9.26 (dd, J=2.2, 0.8 Hz, 1 H) ppm; MS (DCI/NH3) m/z 353 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08486979B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-51de86c2367b43f9a0bd730cba7e425a |
| 出典メモ | uspto-grants-2013_07 |