化工社化工社 化学情報印刷レポート · 研究参考用
5-Hydroxyindole → Indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Hydroxyindole | HCID 16054 | — |
| 反応物 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 反応物 | 4-((Benzyloxy)methyl)-6-chloropyrimidine | HCID 53421259 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Indole | HCID 798 | — |
反応手順
To a solution of 5-hydroxy indole (1.33 g, 10 mmol) and 4-benzyloxymethyl-6-chloro-pyrimidine (2.35 g, 10 mmol) in acetonitrile (20 mL) is added DBU. After 16 h at rt the solution is concentrated under reduced pressure. The residue is purified by FCC (EtOAc/Heptane from 0% to 40%) to give 546-benzyloxymethyl-pyrimidin-4-yloxy)-1H-indole. MS (ESI) m/z 447.0 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541432B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-6e57674adc9f4c228abe882406a9528a |
| 出典メモ | uspto-grants-2013_09 |