Ammonia → HCID 67026145、化合物

反応式

[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[C:11]([F:13])[CH:12]=1)[C:6](=[N:8][OH:9])[NH2:7])#[N:2].FC1C=[C:17]([C:23]#[N:24])[CH:18]=[C:19]([CH:22]=1)[C:20]#N.C(Cl)(=O)C1C=CC=NC=1.N>>[F:13][C:11]1[CH:12]=[C:3]([CH:4]=[C:5]([C:6]2[N:7]=[C:22]([C:19]3[CH:20]=[N:24][CH:23]=[CH:17][CH:18]=3)[O:9][N:8]=2)[CH:10]=1)[C:1]#[N:2]

参加物

反応物 4

HCID 222Ammonia

HCID 82604Nicotinoyl chloride

HCID 27830945-Fluoroisophthalonitrile

HCID 73855262HCID 73855262、化合物

生成物 1

HCID 67026145HCID 67026145、化合物

実験手順

The title compound was prepared according to the procedure of Example 4B using 3-cyano-5-fluoro-N′-hydroxybenzimidamide (Prepared from 5-fluoroisophthalonitrile using the procedure described in Example 4A.) and nicotinoyl chloride (Aldrich). 1H NMR (300 MHz, DMSO-d6) δ 7.77 (m, 1 H), 8.2 (m, 2 H), 8.4 (m, 1 H), 8.6 (m, 1 H), 8.9 (m, 1 H), 9.4 (m, 1 H) ppm; MS (DCI/NH3) m/z 267 (M+H)+.

出典と根拠

ORDレコード: ord-f4cb2100b9394d0d87f330b9aed4a9d6
出典データセット: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08486979B2

反応ノート

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