Sodium Chloride → 5-Nitro-1H-indole-2-carboxylic acid propylamide

HRID 450719

反応式

HRID 450719 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([C:13]([OH:15])=O)=[CH:7]2)([O-:3])=[O:2].[CH2:16]([NH2:19])[CH2:17][CH3:18].[Cl-].[Na+]>CN(C)C=O.O>[CH2:16]([NH:19][C:13]([C:8]1[NH:9][C:10]2[C:6]([CH:7]=1)=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:12][CH:11]=2)=[O:15])[CH2:17][CH3:18]

参加物

6

反応物 3

HCID 5234Sodium ChlorideHCID 7852PropylamineHCID 3512915-Nitroindole-2-carboxylic acid

生成物 1

HCID 670239755-Nitro-1H-indole-2-carboxylic acid propylamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

To a solution of 5-nitro-1H-indole-2-carboxylic acid (6.95 g, 33.7 mmol) in N,N-dimethylformamide (DMF)/pyridine (1/1, 150 ml) N,N′-carbonyl-diimidazole (5.47 g, 33.71 mmol) was added. The mixture was stirred at 80° C. for 1 h. At 0° C. propylamine (9.96 g, 168.56 mmol) was added. The mixture was stirred at 0° C. for 1 h and then at room temperature for 16 h. The solution was diluted with water (2 I). After addition of sodium chloride the product precipitated. After filtration the residue was washed with water and pentane, and dried in a vacuum oven at 50° C. to give the product as a yellow powder.

後処理

  1. stirringThe mixture was stirred at 0° C. for 1 h
  2. waitat room temperature for 16 h
  3. customprecipitated
  4. filtrationAfter filtration the residue
  5. washwas washed with water and pentane
  6. customdried in a vacuum oven at 50° C.

出典と根拠

ORDレコード
ord-1e80d39d99c34aa49004d959ce0d27c2
出典データセット
uspto-grants-2013_07
特許番号
US08486984B2

関連ノート

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