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5-Nitro-1H-indole-2-carboxylic acid propylamide → 5-Amino-1H-indole-2-carboxylic acid propylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Nitro-1H-indole-2-carboxylic acid propylamide | HCID 67023975 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-Amino-1H-indole-2-carboxylic acid propylamide | HCID 62057141 | 95% |
反応手順
To a solution of 5-nitro-1H-indole-2-carboxylic acid propylamide (2.94 g, 11.9 mmol) in EtOH (150 ml) a suspension of palladium on charcoal (10%, 1 g) in EtOH was added. The mixture was hydrogenated at atmospheric pressure. After filtration and removal of the solvents in vacuo the product was obtained as a yellow powder (2.46 mg, 95%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08486984B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-630127751cc1404dbcd018eddda7be57 |
| 出典メモ | uspto-grants-2013_07 |