Monomethylamine methanol → HCID 59478943、化合物
反応式
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[O:12][CH2:13][C:14]1[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[O:19])=[CH:16][N:15]=1.CN.CO>CO>[NH2:3][O:12][CH2:13][C:14]1[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[O:19])=[CH:16][N:15]=1参加物
4
実験手順
To a suspension of 292 mg of 6-{[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]methyl}nicotinamide in 4.4 ml of methanol was added 0.2 ml of a 40% methyl amine/methanol solution, followed by stirring at room temperature for 1 hour. The reaction solution was concentrated, ethyl acetate was added thereto, and the precipitated crystal was separated by filtration and then concentrated under reduced pressure to obtain 146 mg of 6-[(aminooxy)methyl]nicotinamide.
後処理
- concentrationThe reaction solution was concentrated
- additionethyl acetate was added
- customthe precipitated crystal was separated by filtration
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-d3f370b7776744c7b4f0216022f01217
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08486970B2
反応ノート
読み込み中…